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25.5% of People
That Use Naproxen (Aleve) Get Ulcers...
For some it may be the right
choice... for others safer effective options may be a better
choice for your health
 It is amazing when you think about it that more
than 1 in 4 people that take Naproxen (Aleve) get stomach
ulcers. This was at 12 weeks, if you take it longer the rate
increases. Unfortunately all pain relievers have risks so the
question is "what is the right pain relief choice for
you?"
Fortunately, effective
alternatives exist today that have been shown both safe and
effective by a large body of scientific evidence.
For this article we reviewed
thousands of research articles, studies, reports and abstracts
for the supplements that have proven positive effects
relieving different types of pain. For example 15,436 studies
and research articles have been published and recorded at the
National Library of Medicine on Glucosamine (used for treating
arthritis symptoms and pain) alone. |
Source: C J Hawkey, L Laine, T Simon, H Quan, S
Shingo and J Evans. Incidence of gastroduodenal ulcers in patients with
rheumatoid arthritis after 12 weeks of rofecoxib, naproxen, or
placebo: a multicentre, randomised, double blind study.
University Hospital, Nottingham, United Kingdom, USC
School of Medicine, Los Angeles, CA., Merck Research
Laboratories, West Point, PA. |
The good news is if you only need to use a pain reliever for a
short time then as long as you follow the label directions
minimal damage to your body will occur with Naproxen (Aleve) or most
of the common pain relievers on the market.
However for chronic pain lasting longer than 30
days, such as arthritis pain or back pain, real
damage can occur to your body (see Naproxen Compared below).
Fortunately today, research has shown us that you can get
effective healthy pain relief with fewer damaging side
effects.
Natural Pain Relief
Some natural supplements work more like NSAIDs
such as Naproxen by reducing pain and inflammation but often
they work in multiple ways. Others such as those for arthritis pain work by assisting joint health and protecting
joints (attacking the cause) from arthritic degeneration
thereby slowing or stopping its progression.
Natural Anti-inflammatory Pain Relievers For
Back, Arthritis, Strains and Muscle Pain
Some of
the better supplements in this category include Devils Claw
Extract
and Boswellia Serrata Extract. These very effective supplements act to
relieve pain and inflammation without the stomach, heart,
liver, joint degeneration issues that drugs can cause. Each
acts in different ways the help relieve pain and inflammation.
But do they really work?
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You might be surprised to know that in a study
of Devils Claw comparing it to Vioxx (stronger than Naproxen) for it's effectiveness
relieving back pain Devils Claw Extract was not only more
effective during the 6 week study but had significantly fewer
adverse side effects Devils Claw 4.5% vs Vioxx 27.3%.
Source:
Chrubasik S, Model A, Black A, et
al. A randomized double-blind pilot study comparing Doloteffinฎ
(Devils Claw Extract) and Vioxxฎ in the treatment of low back
pain. Rheumatology 2003;42:141-148. (37)
There are numerous other studies
of both Devils Claw and Boswellia that have demonstrated their
efficacy and safety for arthritis and back pain. |
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Natural Joint Support For Arthritis Relief
If you have arthritis you should
consider some of the more effective supplements that
help arthritis by assisting joint health and protect joints
from arthritic degeneration these include Glucosamine,
Chondroitin and MSM. These supplements stop arthritis pain, reduce
inflammation and stiffness by helping solve the underlying
problem rather than just masking the pain.
They tend to act
slower than the above, have a cumulative effect and the effects last longer.
Also studies have shown that these three supplements used in
combination work significantly better that when used by
themselves. All of these supplements are very safe.
Another benefit that is not often mentioned is
that the both Glucosamine and MSM aid the bodies healing power
on connective and soft tissue injuries.
For Arthritis Pain you will get the maximum
relief with natural pain supplements that contain both joint
support ingredients and anti-inflammatory pain ingredients.
Naproxen Compared With One
Popular Natural Pain Reliever
What Is Naproxen?
Naproxen is a non-steroidal anti-inflammatory drug (NSAID)
used as a pain reliever/fever reducer. It is available over the
counter for:
- Headache,
- Minor pain of arthritis,
- B
ackaches,
- Menstrual cramps,
- rheumatoid arthritis in
adults,
- Relief of symptoms of
osteoarthritis
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- Muscular aches,
- Toothaches,
- The common cold,
- Temporary reducing fever
- Reducing swelling and
relieving pain caused by gout.
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Other Names; Naproxen Sodium, Aleve, Naprosyn,
EC-Naprosyn, Anaprox, Anaprox DS.
You can find Naproxen (Aleve) at
your pharmacy |
What Is Zymosine?
Zymosine is a natural
anti-inflammatory, joint support and healing formula used to
relieve joint & muscle pain, support joint health and speed healing
for;
- Relief of symptoms
(inflammation, stiffness and pain) of osteoarthritis
- Slows and possibly stops
the joint degeneration of osteoarthritis
- Speeds healing of cuts
bruises, sprains & strains
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- Relief from the
signs and symptoms (inflammation, stiffness and pain)
of back pain
- Relieves the symptoms of
rheumatoid arthritis,
- Reduces muscles and
connective tissue swelling and pain from strains and
sprains
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You can learn more about or purchase Zymosine
at
Zymosine.com |
| Effectiveness
For osteoarthritis and rheumatoid arthritis
maximum dose Naproxen 1000mg per day has a
comparable effect as other NSAIDs.
Celecoxib (Celebrex),
Rofecoxib (Vioxx), valdecoxib (Bextra), Diclofenac,
Etodolac (Lodine), Indomethacin (Indocin), Ibuprofen (Advil,
Motrin). Naproxen is more effective than 4,000mg of
Acetaminophen.
Significant adverse side effects have been reported for
example a 25.5% ulcer rate at 12 weeks (See Naproxen Risks).
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Effectiveness
Clinical studies (osteoarthritis, rheumatoid
arthritis, back pain, knee pain, hip pain and other joint
pain) conducted demonstrated that the ingredient
in Zymosine had a
pain relieving and/or
anti-inflammatory effect equal to or greater than the
NSAID compared and all ingredients
were better
tolerated with fewer adverse side effects.
Comparison studies of Zymosine ingredients
included: Rofecoxib (Vioxx), Etodolac
(Lodine), Indomethacin (Indocin), Acetaminophen, Naproxen
(Aleve, Naprosyn, Anaprox), Piroxicam (Feldene), Diclofenac (Cataflam,
Voltaren, Arthrotec), Diacerhein, Ibuprofen (Advil, Motrin),
Ketoprofen (Oruvail, Orudis, Actron)
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Naproxen Composition
The chemical names for naproxen and naproxen sodium are
(S)-6-methoxy- แ
-methyl-2- naphthaleneacetic acid and (S)-6-methoxy-แ
-methyl-2-naphthaleneacetic acid, sodium 14 salt, respectively.
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Zymosine Composition
Zymosine is a pharmaceutical grade natural herbal
supplement complex that contains: boswellia serrata extract, boron,
bromelain (pineapple), devils claw extract, glucosamine, chondroitin
or methylsulfonylmethane (MSM).
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How Do I Take Naproxen?
When taking an over-the-counter Naproxen product, 1 tablet
(220
mg) should be taken every 8 to 12 hours while symptoms last.
You may take 2 tablets within the first hour of symptoms for
the
first dose. However, you should not exceed 2 tablets (440 mg)
in any 8 to 12 hour period or 3 tablets (660 mg) in a 24-hour
period.
If your healthcare provider has prescribed
Naproxen to you, you should take it according to their
directions. Typically 1000mg to 1500mg per day.
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How Do I Take Zymosine?
The regular recommended dosage of
Zymosine is 2 capsules 3 times a day. This can be increased to 3
capsules 3 times a day if needed. Also if taken for
Osteoarthritis you may be able to reduce your dosage after 30 to
60 days to 1 capsule 3 times a day.
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Does Naproxen interact with other drugs or
food?
Tell your healthcare provider about all the medicines you
take,
including prescription and non-prescription medicines,
vitamins,
and herbal supplements. Your healthcare provider may have to
adjust your dose or watch you more closely if you take any of
the
following medications:
Certain blood pressure medicines called ACE inhibitors
Furosemide (Lasix)
Lithium
Methotrexate
Warfarin (coumadin)
Aspirin
Other NSAIDs |
Does Zymosine interact with other drugs or
food?
Drug interactions with ingredients
are minimal. However always tell your healthcare provider
about all the medicines you take, including prescription and
non-prescription medicines, vitamins, and herbal supplements. |
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Naproxen Risks |
Zymosine Risks |
Heart and Cardiovascular
System -
Ingredients Increase Risks
FDA Alert
[12/23/04]: Based
on emerging information, the risk of cardiovascular and cerebrovascular events may increase among patients taking
naproxen (Aleve). FDA recommends patients not exceed the recommended
dose. For more information about these risks, refer to the FDA
Alert for Healthcare Providers. |
Heart and Cardiovascular System -
Ingredients
Considered Safe
No heart or cardiovascular risks have been
reported from any clinical studies or research on any of the
ingredients in Zymosine. |
| Stomach and GI
Tract Ulcers or Bleeding -
Ingredients Increase Risks
Naproxen can cause stomach ulcers that
bleed. The chance of
this serious problem increases the longer you take Naproxen
and
with higher doses of Naproxen. Stomach bleeding can also
happen suddenly while you take Naproxen. Stop taking Naproxen
and call your healthcare provider right away if you get:
A burning stomach pain
Black bowel movements that look like tar
Vomit that looks like blood or coffee grounds
On average 25.5% of persons
using Naproxen will get a stomach ulcer after using Naproxen
for 12 weeks this risk increases with continued use.
Source: C J Hawkey, L Laine, T Simon, H Quan, S
Shingo and J Evans. Incidence of gastroduodenal ulcers in patients with
rheumatoid arthritis after 12 weeks of rofecoxib, naproxen, or
placebo: a multicentre, randomised, double blind study.
University Hospital, Nottingham, United Kingdom, USC
School of Medicine, Los Angeles, CA., Merck Research
Laboratories, West Point, PA.
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Stomach and GI Tract Ulcers or
Bleeding -
Ingredients
Considered Safe No
increased risk of stomach ulcers
or bleeding have been reported from clinical studies or
research on any of the ingredients in Zymosine. |
Kidney problems -
Ingredients Increase Risks
Studies show that the risk of
Acute Renal (Kidney) Failure increase by approximately 3 times
when taking Naproxen. Naproxen can cause serious kidney
problems, including sudden kidney failure or worsening of
kidney problems that you already have.
Source: Consuela Huerta, MD, Jordi Casellsague, MD, Cristina
Varas-Lorenzo MD, PhD,, Luis Alberto Garcia Rodrigues, MD.
Nonsteroidal Anti-Inflammatory and Risk of ARF in the General
Population. |
Kidney Problems -
Ingredients
Considered Safe
No increased risk of kidney problems have been reported from clinical studies or
research on any of the ingredients in Zymosine.
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Joint Degeneration -
Ingredients Increase Risks
and Speed Joint Degeneration
Naproxen
interferes with the bodies joint regeneration process by
inhibiting glycosaminoglycan synthesis in the body. This
increases the amount of joint degeneration over time.
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Joint Degeneration -
Ingredients
Considered Safe and Considered Joint Protective
Glucosamine, Chondroitin and MSM
contained in Zymosine assist glycosaminoglycan synthesis
and joint regeneration. Studies demonstrate that they slow and
possibly stop the progression of arthritis joint degeneration. |
Liver damage -
Ingredients Increase Risks
Naproxen increases the incident of
liver damage by 15.7%.
Stop taking Naproxen and
tell your doctor right
away if you have nausea, vomiting, tiredness, loss of
appetite,
itching, yellow coloring of skin or eyes, flu-like symptoms,
and
dark urine.
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Liver damage -
Ingredients
Considered Safe
No increased risk of liver damage have been reported from clinical studies or
research on any of the ingredients in Zymosine.
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Allergic reactions -
Any drug, food or
supplement may cause an allergic reaction special caution
should be used in the following circumstances.
Naproxen can cause serious
allergic reactions, including asthma-like symptoms (problems
breathing, swallowing, and wheezing) and rash. Allergic reactions
may occur is your have ever had asthma, rhinitis, or nasal
polyps after taking aspirin or other NSAID medicines or have
an Aspirin sensitivity.
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Allergic reactions -
Any drug, food or
supplement may cause an allergic reaction special caution
should be used in the following circumstances.
As a
dietary supplement the ingredients in Zymosine like food may
cause allergic reactions. Therefore use
caution if you have a known allergy to any of the ingredients; boswellia serrata, boron, bromelain (pineapple), devils claw,
glucosamine, chondroitin or methylsulfonylmethane (MSM). |
Fluid retention -
Ingredients Increase Risks
Naproxen can cause
fluid retention (holding of
water in your body) and swelling. Fluid retention can be a
serious
problem if you have high blood pressure or heart failure.
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Fluid retention -
Ingredients
Considered Safe
No increased risk of fluid retention have been reported from clinical studies or
research on any of the ingredients in Zymosine.
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Pregnancy and Breastfeeding -
Not recommended. Always
consult a physician before taking any drug or supplement when
pregnant or nursing
Do not take Naproxen during
your last 3 months of
pregnancy because it may cause problems in the unborn child or
complications during delivery. Tell your doctor if you are
pregnant or planning to become pregnant. Tell your doctor if you
are breast-feeding.
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Pregnancy and Breastfeeding -
Not recommended. Always
consult a physician before taking any drug or supplement when
pregnant or nursing
As with most supplements the ingredients in Zymosine have not
been studied in pregnant women therefore it is not recommended
to be used by pregnant or breastfeeding women.
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Who Should Not Take Naproxen?
Do not take Naproxen if you:
Ever had asthma, rhinitis, or nasal polyps after taking
aspirin
or other NSAID medicines. Aspirin-sensitive patients should
not take Naproxen as reactions have the potential of causing
death.
Have advanced kidney disease
Are pregnant, especially your last 3 months. |
Who Should Not Take Zymosine?
Do not take Zymosine if you:
Ever had a serious allergic reaction to any of the
ingredients.
Are pregnant, especially your last 3 months. |
What Should I Do Before Taking Naproxen?
Ask a doctor or pharmacist before using Naproxen if you:
Are trying to get pregnant, are pregnant, or are
breast-feeding
Have or had angina (chest pain), heart attack, or blocked
artery in your heart
Have kidney problems
Have liver problems
Have heart failure
Have high blood pressure
Retain fluids (hold extra body water and swell)
Had an allergic reaction to aspirin or other NSAID medicines
Had a serious stomach problem in the past
Have or had any other medical problems or allergies |
What Should I Do Before Taking
Zymosine?
Ask a doctor or pharmacist before using Zymosine if you:
Are trying to get pregnant, are pregnant, or are
breast-feeding
Had an allergic reaction to any of the ingredients
Have or had any other medical problems or allergies |
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Additional/Purchase Information
You can find Naproxen (Aleve) at
your pharmacy |
Additional/Purchase information
Visit
Zymosine.com to learn more about or purchase Zymosine
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If you have any questions or comments please
let me know.
Steve Smith
ssmith@pain-reliever.info
| Information
on this site is for informational purposes and is not
meant to substitute for the advice provided by your own physician
or other medical professional. You should not use this information
for diagnosing or treating a health problem or
disease, or prescribing any medication. |
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