Bextra Valdecoxib side effects
 

    Tylenol Information

  

Brand Name: Tylenol
Drug Name: Acetaminophen

DESCRIPTION

Acetaminophen is used to relieve pain and reduce fever. Unlike aspirin, it does not relieve the redness, stiffness, or swelling caused by rheumatoid arthritis. However, it may relieve the pain caused by mild forms of arthritis.

FDA Alert [12/23/04]: Based on emerging information, the risk of cardiovascular and cerebrovascular events may increase among patients taking naproxen (Aleve). FDA recommends patients not exceed the recommended dose. For more information about these risks, refer to the FDA Alert for Healthcare Providers.

Cautions

Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to acetaminophen or aspirin. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy—Although studies have not been done in pregnant women, acetaminophen has not been reported to cause birth defects or other problems.

Breast-feeding—Although acetaminophen passes into the breast milk in small amounts, it has not been reported to cause problems in nursing babies.

Children—This medicine has been tested in children and has not been shown to cause different side effects or problems than it does in adults. However, some children's products containing acetaminophen also contain aspartame, which may be dangerous if it is given to children with phenylketonuria.

Older adults—Acetaminophen has been tested and has not been shown to cause different side effects or problems in older people than it does in younger adults.

Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your health care professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

 

Other medical problems—The presence of other medical problems may affect the use of acetaminophen. Make sure you tell your doctor if you have any other medical problems, especially:

  • Alcohol abuse or
  • Kidney disease (severe) or
  • Hepatitis or other liver disease—The chance of serious side effects may be increased
  • Phenylketonuria—Some brands of acetaminophen contain aspartame, which can make your condition worse

Pain Relievers

Aspirin - Acetylsalicylic Acid

Acetaminophen - Tylenol

Bextra - Valdecoxib

Celebrex - Celecoxib

Ibuprofen - Advil, Motrin

Naproxen - Aleve

Vioxx - Rofecoxib

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 Check with your doctor:
  • If you are taking this medicine to relieve pain, including arthritis pain, and the pain lasts for more than 10 days for adults or 5 days for children or if the pain gets worse, new symptoms occur, or the painful area is red or swollen. These could be signs of a serious condition that needs medical or dental treatment.
  • If you are taking this medicine to bring down a fever, and the fever lasts for more than 3 days or returns, the fever gets worse, new symptoms occur, or redness or swelling is present. These could be signs of a serious condition that needs treatment.
  • If you are taking this medicine for a sore throat, and the sore throat is very painful, lasts for more than 2 days, or occurs together with or is followed by fever, headache, skin rash, nausea, or vomiting.

Check the labels of all prescription and nonprescription (over-the-counter [OTC]) medicines you now take. If any contain acetaminophen, check with your health care professional. Taking them together with this medicine may cause an overdose.

If you will be taking more than an occasional 1 or 2 doses of acetaminophen, do not drink alcoholic beverages. To do so may increase the chance of liver damage, especially if you drink large amounts of alcoholic beverages regularly, if you take more acetaminophen than is recommended on the package label, or if you take it regularly for a long time.

Taking certain other medicines together with acetaminophen may increase the chance of unwanted effects. The risk will depend on how much of each medicine you take every day, and on how long you take the medicines together. If your medical doctor or dentist directs you to take these medicines together on a regular basis, follow his or her directions carefully. However, do not take any of the following medicines together with acetaminophen for more than a few days unless your doctor has directed you to do so and is following your progress:

  • Aspirin or other salicylates
  • Diclofenac (e.g., Voltaren)
  • Diflunisal (e.g., Dolobid)
  • Etodolac (e.g., Lodine)
  • Fenoprofen (e.g., Nalfon)
  • Floctafenine (e.g., Idarac)
  • Flurbiprofen, oral (e.g., Ansaid)
  • Ibuprofen (e.g., Motrin)
  • Indomethacin (e.g., Indocin)
  • Ketoprofen (e.g., Orudis)
  • Ketorolac (e.g., Toradol)
  • Meclofenamate (e.g., Meclomen)
  • Mefenamic acid (e.g., Ponstel)
  • Nabumetone (e.g., Relafen)
  • Naproxen (e.g., Naprosyn)
  • Oxaprozin (e.g., Daypro)
  • Phenylbutazone (e.g., Butazolidin)
  • Piroxicam (e.g., Feldene)
  • Sulindac (e.g., Clinoril)
  • Tenoxicam (e.g., Apo-Tenoxicam)
  • Tiaprofenic acid (e.g., Surgam)
  • Tolmetin (e.g., Tolectin)

Acetaminophen may interfere with the results of some medical tests. Before you have any medical tests, tell the person in charge if you have taken acetaminophen within the past 3 or 4 days. If possible, it is best to call the laboratory where the test will be done about 4 days ahead of time, to find out whether this medicine may be taken during the 3 or 4 days before the test.

For diabetic patients:

  • Acetaminophen may cause false results with some blood glucose (sugar) tests. If you notice any change in your test results, or if you have any questions about this possible problem, check with your health care professional. This is especially important if your diabetes is not well-controlled.

For patients taking one of the products that contain caffeine in addition to acetaminophen:

  • Caffeine may interfere with the results of a test that uses adenosine (e.g., Adenocard) or dipyridamole (e.g., Persantine) to help find out how well your blood is flowing through certain blood vessels. Therefore, you should not have any caffeine for 8 to 12 hours before the test.

If you think that you or anyone else may have taken an overdose of acetaminophen, get emergency help at once, even if there are no signs of poisoning. Signs of severe poisoning may not appear for 2 to 4 days after the overdose is taken, but treatment to prevent liver damage or death must be started as soon as possible. Treatment started more than 24 hours after the overdose is taken may not be effective.
 Acetaminophen Side Effects
Check with your doctor immediately if any of the following side effects occur:
  • Rare: Yellow eyes or skin

Also, check with your doctor as soon as possible if any of the following side effects occur:

  • Rare:  Bloody or black, tarry stools;  bloody or cloudy urine;  fever with or without chills (not present before treatment and not caused by the condition being treated);  pain in lower back and/or side (severe and/or sharp);  pinpoint red spots on skin;  skin rash, hives, or itching;  sores, ulcers, or white spots on lips or in mouth;  sore throat (not present before treatment and not caused by the condition being treated);  sudden decrease in amount of urine;  unusual bleeding or bruising;  unusual tiredness or weakness 

Overdose Symptoms

  • Diarrhea;  increased sweating;  loss of appetite;  nausea or vomiting ;  stomach cramps or pain;  swelling, pain, or tenderness in the upper abdomen or stomach area 

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.



DOSAGE AND ADMINISTRATION

The dose of acetaminophen will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of acetaminophen. If your dose is different, do not change it unless your doctor tells you to.

The number of capsules, tablets, teaspoonfuls of oral solution or suspension that you take, the amount of oral granules or powders that you take, or the number of suppositories that you use, depends on the strength of the medicine. Also, the number of doses you use each day and the time allowed between doses depend on the strength of the medicine.

  • For oral dosage forms (capsules, granules, powders, solution, suspension, or tablets) and rectal dosage forms (suppositories):
    • For pain or fever:
      • Adults and teenagers—325 or 500 milligrams (mg) every three or four hours, 650 mg every four to six hours, or 1000 mg every six hours as needed.The total dose should not be more than 4000 mg (for example, eight 500–mg tablets) a day.
      • Children—Acetaminophen dose is based on the child's age.
        • Infants up to 3 months of age: 40 mg every four hours as needed.
        • Infants 4 to 12 months of age: 80 mg every four hours as needed.
        • Children 1 to 2 years of age: 120 mg every four hours as needed.
        • Children 2 to 4 years of age: 160 mg every four hours as needed.
        • Children 4 to 6 years of age: 240 mg every four hours as needed.
        • Children 6 to 9 years of age: 320 mg every four hours as needed.
        • Children 9 to 11 years of age: 320 to 400 mg every four hours as needed.
        • Children 11 to 12 years of age: 320 to 480 mg every four hours as needed.

Storage

  • Keep out of the reach of children.
  • Store away from heat and direct light.
  • Do not store acetaminophen tablets (including caplets and gelcaps), capsules, or granules in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
  • Keep the liquid and suppository forms of this medicine from freezing.
  • Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

 

 

Information on this site is for informational purposes and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use this information for diagnosing or treating a health problem or disease, or prescribing any medication.

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